AES/EBU in the Axe FX II. How it works?

[Bakerman]

Yep, iin the advanced options of StudioOne you can release the driver in the background so switching from external sync source for the audio interface while recording the wet and dry tracks and then re-amping with the audio interface as master seems to work fine. But just beware that if you click outside of your DAW while recording it will stop.

Reaper's pretty nice in this department: it will always keep recording if unfocused/minimized, and for driver release you have a choice of whether it needs to lose focus or just be stopped, plus whether or not it will release it when tracks are record-armed.