I enjoy amp gain, drive pedals into a nearly clean amp, and drive pedals into a pretty crunchy amp.
But will say this, which no doubt means I have to hand in my license to Drive: I have never, not once, put a Tube Screamer in front of any amp and thought it improved anything.
Lately I've been digging the Jam Ray in front of a the Class A 15 TB, and the Hoodoo with the Dirty Shirley, and I've dug the OCD, and others. But no TS. Even if the pedals I do like are slight variants on a TS, the TS itself has just never worked out for me.