Well... I have no wet effects, just drives and tone shapers in front of the AXE FX...
I have a Fuzz Face NKT275 first-in-signal...fuzzes are unique, and the AXE FX model is very good/convincing, but I like a real one first in line with Strats...
Followed by an Ultimate Octave Fulltone I just use for the octavia effect (although the AXE does a convincing one, this just saves me Drive pedal options)
Then a Tone Concepts "The Distillery" pedal that Dweezil Zappa turned me onto that I LOVE and use for solo boosts, works great
Then a Solid Gold EFX Funkzilla pedal I hardly use... sometimes swap it out for either a Wampler TomQuayle Fusion Drive or a SImble drive by the Mad Professor.
Then a Ditto pedal just for quick looper in practicing
and at the end, an RC Boost that I use on single coils going into the AXE FX. Again, The AXE FX does a great RC boost, but I like to keep my AXE FX Drive block pedal options open for other things...
Some of this is to free up IA switches on the MFC so I can do more things, like Amp X/Y, Drive X/Y Delay X/Y, Scene 1/2, and Wildcards.