Biggest worries: not Feeling the POWER and girth in my tone that I am used to.
Not being able to dial in my high gain tones for a live setting/high volume
Needing to change something "on the fly" at a gig, and not being comfortable or knowledgeable to do it quick and efficiently.
The "random" issues people seem to have at times, (axe freezing, not knowing how to do something/ use the unit correctly etc)
Basically, I would be probably be more "scared" to use it live, than my live physical amps due to the last reason listed above. How do you know when you are "ready" to use the axe live and get the most out of it? These are the things that are really holding me back, and always have. sigh..............
I recently bought an RCF 310ART monitor to go along with the Axe II, and I practice with a live drummer, bass, acoustic, and singers and am PLENTY loud; love the way it moves air. Love the way it sounds, even though that is one of the lower end of the RCF series. Still have a couple tube amps, but haven't used them in quite awhile; but don't have a second Axe for backup.
It is so easy to bring it home after practice and hook it up to a couple studio near field monitors and have an excellent practice/tweaking rig that doesn't blow you away. It records superbly as well.