Probably the only real downside is that I spend time messing with it when I should be playing. With my old amp, I'd mostly walk over, turn it on, and play. Now, I get the itch to check out new presets, maybe buy a pack of them, catch up on software updates, try out new features, etc. While I'm glad to have the functionality, my time was better focused before.
Last weekend, I borrowed a THR10X from a friend of mine. I had it in the living room all weekend, and had a blast playing. I might have twisted a knob or two every so often, but it was kind of nice just having something to turn on and play. Sounded pretty good for a tiny speakered lunchbox.