I have a really specific strategy for the way I use the FC-12. The Effects layout is the one that I have customised most, and is my "home" layout. I have laid it out pretty much how I used to layout my effects pedals, and colour coded the switches to remind me of pedals I used to use a lot. Compressor is red like a Dyna Comp, overdrive green like a Tube Screamer, Flanger purple like a Small Clone, Phaser orange like a P90, etc. I'm getting a bit long-sighted now I'm in my mid-50s, and could probably do with a little bit of sight correction to read the scribble strips better, but in my normal mode of playing that layout is really recognisable, kind of familiar in colours, and I use it like a bunch of stomp boxes laid out in front of me.
I think we already discussed that I have some "long presses" that take me intuitively between the Scenes and Presets layouts, and I'm usually working between Effects and Scenes. Scenes are all set up either as important starting points (clean, overdrive, fuzzy rhythm), or setups that would involve too much tap dancing to get to easily (compressed lead with overdrive and delay, monster fuzz with aggressive flanger and helicopter landing chopped tremolo). I use pretty much the stock Scenes layout, and have left the preset up, preset down buttons active. If I start running out of scenes for a particular setup I'll duplicate the preset to the next one up just for the convenience of moving swiftly between songs. My main preset is duplicated 5 times at the moment, so that I have scenes available with ever extended levels from basic rock/pop through to serious mayhem, idiocy and wigging out on 4 of them. The 5th is just a really specific set of them for one particular song that needs very specific simultaneous effects switching across 5 scenes, and some slightly different delay times to what I'd normally use. Importantly for my tiny brain, I'm only ever a long press away from getting back to the relative familiarity and safety of the Effects layout, where I can breathe a minor sigh of relief.
The thing I miss most about the Axe FX II is the ability to have an FxUnits RAC12 sitting in the rack. Not sure if you ever came across them, but it was essentially a set of amp controls in the rack, and meant you could set up to have all the usual amp controls at your fingertips whenever you wanted them. I still don't really have a strategy to get that fluidity back without putting my reading glasses on and pressing a few buttons on the front panel. On balance, the FC-12 is such a huge leap forwards from the MFC-101 that it's not that huge a deal, but I do miss just having bass, middle, treble, presence, gain and level controls just as if it's a real amp behind me. Having said that, I used to put myself in all sorts of trouble by pressing the "save" button mid gig and saving block state changes to scenes and presets that I really hadn't intended to.
That's kind of the tip of the iceberg, as I also have strategies for less complex setups, especially those where I use the volume control of the guitar and the way I pick for dynamics, and with those ones I often switch between amps in the Channels layout (to which I have added a few effects switches in familiar colours, but fewer of them, because I don't need them for those playing styles). But most of the ideas are variations on the theme of having a home layout that feels like stomp boxes.
Hope that's interesting, if maybe not that helpful!
Liam