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USB audio randomly distorted


After a while when using my mac for music playback, the audio from the Axe will be horribly distorted (like a constant high pitch squeal). A power cycle of the Axe usually fixes it. When in this state playing guitar through the Axe sounds fine. I've experienced this on my machine before and after doing a full OS installation. Other USB interfaces do not have this problem.

It's a Mac Pro 2010 running Mojave. Before I go adding a PCI USB card to try that, does anyone have other suggestions on what I could try first?
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