I've been battling the last couple of weeks with my strat and some gainier sounds- everything I had was dialed in for my Gretsch, and the drive just wasn't translating the way that I wanted it with the Strat. I ended up starting from scratch- I stopped trying to get my Gretsch patches to simply respond the same way, and it wasn't the Axes fault- Not every rig sounds great with every guitar in the analog world too.
One formula that seems to have worked well was experimenting with the Dumble sounds with the Strat- they're nice and thick, so you can put a low output Strat into them and it doesn't sound weak. I used the OD2 model, lowered the gain and input drive, bumped up the input trim just a little, and raised the master quite a bit. That last part- raising the master- that was the key. I love the sound of the Dumble power amp drive! There are plenty of ways to add drive to the whole rig, so experiment a bit, and I bet you might find some nice sounds.
That being said, in the old days, I could never get a strat to sound right through a Marshall, and apparently I still can't! (Unless there's a fuzz in the mix- that's a whole different story.)
When I get home, I'll try to post the Dumble patch. It might help, and any suggestions are welcome.