The only thing I can tell you that on the last Lanfear album we used a Mesa Recto/Engl combination (Axe-FX I).
At that time there was no Angel Severe so I had the "Energyball" dialed in. The EB is definitely not one of my faves in the Axe-FX and the single sound wasn't that great, but it added a certain "flavour" to the Mesa and everything sounded what you maybe would call smoother. I don't think that I would use two amps on the next album, though. Simply not necessary with the Axe-FX II.
I used OH IRs and I still love all their stuff. My suggestion: If it's too grainy with less gain try out different IR mixes before anything else. Always helped me