I use 2 QSC 10s, plenty of power for most gigs, works very well with the axe 3 . beautiful sound.I used one QSC K12 for better part of 10 years stood up, and then the CLR for the last 3 or so and I also stand it up, I don't like it pointing at my ears. Both are plenty for any type of gig I could throw at them.
Totally agree for outdoor and larger rooms. The FRFR's don't sound as good in those settings. In a few cases, for outdoor and larger stage gigs, I have asked for two wedges. I have one wedge set up in front of me with vocals, other instruments and a little of my guitar and a separate wedge on one side or behind me where the mix is only my guitar. That has worked really well and the combo allows me to hear the guitar very well without being too loud and I end up hearing the rest of the band much better. Worth a try IMO. Also, reduces the schlep considerably. You just need to make sure the sound crew has enough wedges and they are decent.I used to try to have the FRFR "carry the room", used QSC K12/k10/k8 and also the friedman ASM12-R. In the end, especially outdoors and/or with a loud drummer I couldn't keep up without just blasting everyone on stage as well. In the end it's better to have a wedge for you and still go into the PA, even if it's just a pair of 12Inch wedges on stands.
One of the main benefits for using a power amp and regular guitar cab to "carry the room" is that since most cabs are very directional, you can get your volume exactly where you need it and it's mainly for your benefit. Obviously YMMV depending on speakers, cab etc.
I have used an AX8 with a single Atomic CLR frfr for club/bar gigs for several years with good results. I will say there times when the band gets ridiculous with stage volumes. Those are the only times when I have difficulty hearing the CLR when I move further away.
I have since replaced the AX8 with an AxeFX3. Unfortunately I have yet to play out live with it since all our gigs to date have been cancelled. Looks like I'll have a shot to hear it live towards the end of June. Just in case, I plan on using 2 CLRs which should give me better coverage.