In the studio, it was pretty basic - a Strat through his Fender Vibrolux with reverb and compression (Dan Armstrong Squeezer compressor). Live, as in Alchemy, he used that while incorporating a few other kinds of Fender amps including the Super Reverb, among other brands. He plays the famous red Strat, for the rhythm he uses the middle pickup, for leads the uses the middle/bridge. In interviews he also mentions using the neck pickup to occasionally fatten up his leads (the breakdown part comes to mind). Obviously you need to work on your finger picking game, chords and leads. Using my Strat through a 68' Fender Deluxe Reverb with a Keely Compressor Pro and a good dose of spring reverb, I can nail the tone from Sultans, studio and Alchemy. The bite comes from cranking the amp. You should be able to dial that in with your AX-FX.