Something to consider...
While an Axe Fx II with FRFR speaker(s) and a flat, powerful amp will allow you to model all the currently supplied and vintage amps/effects so accurately it's spooky, that doesn't mean you can't get good tones otherwise. You have to decide whether you want/need an perfect representation of the numerous amps/speaker(s) combinations that exist in the real world. It's entirely possible to modify the settings to get an absolutely great tone out of anything. Or, at least something that will make you happy, Happy, HAPPY! The models at this point in the thing's evolution are superb, so you can think of it as a given. For instance, if you had a Marshall JCM 800 head, you could plug it into a pretty wide variety of bottoms and each would sound different. Same with the Axe. Turn off the cabinet modelling, and go for it. You'll smile at the sky, guaranteed. But, who's to say which is best? There's no accounting for taste. The joy of a FRFR solution is that you can change amps and cabs at the push of a button. But, what if you don't need to? For numerous examples, look at the pros. Robin Trower uses a pretty limited amp/speaker combination. What use has he for an Axe Fx? So he can model some short stack JCM800s? Why? He probably has a warehouse full of them.
When I first got my AxeFx, I ran it through a pair of 112 bottoms I built. Nice units, if I must say so myself. But, everybody said "yer nutz!" Too limiting. Well, ok. Sounds pretty damn good to me, better than anything I'd had before. But, peer pressure and all that... so I cheaped out and bought some full-range PA speakers from Carvin. World of difference. Now I could hear differences I never heard before, and much more accurate representations of what I was supposed to be modelling. Like going from black & white photos to color. Still, not quite the resolution you'd want if you were looking at something in real life. So, you take the next step.
Now I can get a pretty accurate representation of many amp/cab combinations, but I've gotten to the "Who cares?" point. I never wanted a Mesa Boogie. Never wanted a Vox. Or, at least I'd never have paid for one. But, they're certainly handy sometimes, if you're trying to cover somebody else's tone. But for me? I have my own taste.
So, while there's a lot to be said for FRFR speakers and flat amps, mainly what they do is show off the AxeFx's incredible accuracy. Keep in mind that it's infinitely variable, and you may be able to get to some point that makes you happy. I mean, who hasn't bought an amp and replaced the speakers or (something)? Or, piled 297 sfx in front of it?
Don't sweat it, is what I'm saying. Wait and see if you have a problem before you let other people say you have a problem.