I don't know if what you're experiencing has to do with magnetism or electrical grounding, but I just want to throw in that picks make a huge difference in sound for me in using FRFR. That's why I change picks for different sounds - Before the Axe I had just use stubbys or fender teardrop picks. I used to sharpen picks on the carpet because it helped me play but also helped bring up the clarity. Currently with the Axe FX, for both tone and control I like using V picks (the mediums for everything, and the screamers for stuff where I need more pinch harmonics). But I also use "treated" V picks using various things like fingernail hardener, epoxy, kitchen counter chip repair materials (changes the sound and makes 'em last and last). I find the treated picks can be adjusted for different sounds. Some of the picks by V-picks don't do as well for sweeping as for alternate picking, causing too much of a "chirp" sound (can't remember which one right now - maybe the one they call the "Dimension"), but when they've been given a coat of "hard as nails" this solves the issue and they feel and sound great. Some coats are applied with a brush like the fingernail products and counter chip repair, and others need to be applied using a dropper and then filed or sanded off. There are coating materials that have more bounce, and others that have more edge, including maybe what you describe if its just a kind of static-like high end. It could just be the molecules in the metal going through the molecules on the guitar string being super-isolated by the clarity of the Axe in your listening setting - whereas some cabs and noisy rooms "hide" those sorts of details. I also have a great deal of trouble if forced to use a pick I don't think is best. As for favorite picks, I like the feel of Jazz IIIs but the sound is not particularly good with my 09 strings, and they're not really thick enough in my mind for fast string shifting so I just use the V-pick mediums which sound bright and very full - there can be a noticeable chirp that might or might not be acceptable depending on your focus and needs. The interesting thing is using a pick with a full mid range and chime can make thin strings sound not so thin. But metal picks sounded dull to me and weren't very helpful for my picking technique. I would like to try copper now that I've heard of it if it doesn't sound dull. Anyway, if you have never tried treating your picks, and the problem persists, you could try it - I completely understand about not wanting to change them as right hand technique is so dependent on keeping the same kind of pick. Treating picks with coatings has helped me slightly change the EQ when a pick that is very playable doesn't sound the way I want.
