Monitor connections with Interface and Mixer

Hello, I have a Mackie 1402VLZ3 and a MOTU M4 (4 in/out interface). I have a pair of Headrush 112's and a pair of M Audio BX5A D3's.

I plug my AXE FX 3, Kemper etc into the mixer and out of the mixer into the M4.

My question is what is the best way to connect the speakers(both pairs have dual inputs)
Right now I have the Mackie mains out to the Headrush, the M4 outs to the BX5's. Should I utilize the Control Room outs/ALT 3/4 outs?
 
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