Mixer Preamps and Processors?

Forgive me if this sounds dumb. But if I plug my Axe Fx or any processor via the xlr cables into the mixer mic inputs will the quality of the preamps of the mixer make a difference or does it only matter for microphones?
 
Modern mixer preamps are pretty dang good if you keep the gain structure in the sweet zone. Depending on your mixer, switching the input to Line Level on the mixer may bypass the mic preamp entirely.

Unless you have a crappy mixer or the mixer is being run badly, you won’t hear the effects of the mixer in any realistic live situation.
 
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