I have a Standard 50s sitting next to an S2 594 double-cut.
They're both fantastic guitars. Mine both have mostly standard wiring and SD Seth Lovers. There's no coil splitting in the PRS, but they both have a taper/range resistor on the bridge tone pot (because I literally never turn the birdge tone all the way up).
But, they're not the same guitar. If nothing else, the PRS's pickups are farther away from the bridge. The overtone series they pick up is different, and they will always sound different. The hardware, frets, and the geometry of everything outside of the nut & bridge are different too, but people are going to argue about that ad nauseum. But the pickup position thing is inarguable. The finishes are actually more similar than you think...modern non-CS Gibsons have a thin poly top coat. They're not pure nitro. The PRS is probably 2lbs lighter too, and the body is a good bit thinner.
The way I'd describe the sound is that the PRS sounds heavier and more hi-fi-ish.
It's kind of like the difference between a Les Paul and an SG, except in the opposite direction. The bridge is also "lower" (away from the headstock) on the PRS, so it feels substantially smaller.
For whatever it's worth, except for some very minor cosmetic defects (the finish kind of bleeds onto the binding), my 2019 Standard 50s is great. It doesn't have the flaws people complain about, and the very minor cosmetic things just don't bother me. My PRS also has a ding all the way through the finish to the raw wood on the back of the upper horn because I just bumped something exactly the right way to do it.
The Standard 50s is a weird mix of specs...it has the shorter neck tenon that the 1960 Les Pauls had but a thicker neck profile at least than the Standard 60s...though I haven't played a real burst, so no idea how close either is. The only vintage LP I've ever played was a 1952, and my Standard 50s neck isn't near that fat.
They're both really resonant and lively guitars, no dead notes, etc.. They really are both great.
If forced...I'd say that I think the PRS is "nicer". But, I still generally like the Les Paul more, at least for the sounds I like right now. But, I pick them both up.
It's worth playing them if you can. They're not the same guitar.
