I heard a trick a while back about setting the room values to mimic your head and ears, iirc you would set room level at 50%, size at minimum and mic spacing at 0.1-1%, I'll have to find the source but it sounds pretty decent to me. I don't use it usually because I've always listened to amps through headphones like the youngster I am, but it helps with the amp in the room tone.
Edit-
here's the link.
I love using the preamp. I haven't set almost to clipping or very slightly in the red depending on the patch for cleans and vintage crunch, but keep more headroom for high gain. It brings a bit of color and saturation to the tone, which I enjoy. Depends on the patch, same need less, some like more, some don't sound good with any.