Just added to my comment:I'd be interested in hearing some comparison clips, well controlled, so the only difference is cable direction.
I'd also like to understand the scientific basis for the difference, the physics that makes that difference happen.
It also seems unlikely that the audio and instrument worlds would have missed this all these years, with all the attention that gets paid to cultivating awesome tones.
There is a theory that the direction of the winds in the shielding of the cable can have an effect on the capacitance of the cable, and some will talk about the direction in which the wire was drawn before it was twisted together.
No one can convince anyone. You will have to try it yourself.