I've been lucky with using stereo patches in a mono environment.
What I do is first try with setting the output mode in the IO menu to "sum l+r". Then I audition all the patches I plan on using, and look carefully for any phasing issues. Any patches that do have some phasing issues are either checked off my list of usable ones, or I quickly edit the patch to "fix" it for proper mono use (get rid of any phase reversals, etc.).
If I'm really stuck, I will try setting the output mode in the IO menu to "copy l->r", but I prefer NOT to use this (because you completely lose the right channel, including any stereo ping-pong delays that are panned right). In that setting, many of my patches have delay times that are double the usual (because the repeat on the right side is missing altogether). So I seriously try to avoid it.
Like I said, using "sum l+r" and careful auditioning, I can usually get away with it.
Oh, and like Java said, some dual amp settings don't work well once collapsed to mono. In my case, I never use two amps at once (most of my patches have two amp blocks, but I only use one *or* the other, not both at the same time), so I'm ok.
Don't give up, it's workable.
Daniel