As a long time Wampler Ego user I've been wrestling with the same issue. Just yesterday I cam close enough to my Ego to remove it from the AF3 FX loop. That being said, it's not a 1:1 at this point as the Ego seems to fatten the notes in a very special way. However, the key for me was the Tube Compressor as it adds a bit more grit/coloration than the other types I've been trying to achieve this:
Play with the Threshold in small increments;
Adjust the output Level to push your Amp;
Try the Mix (with more aggressive compression) knob to replicate the Ego's Blend pot.
(Next task is to replicate the warmth of my v3 OCD pedal... the key is in the Drive Block's built-in EQ)
View attachment 74692