Lightningboy
Experienced
As someone mentioned the way you have the amp set up may be an issue and you only mentioned what cables you are using and nothing on the amp settings and physical connections. If the amp is switched to Bridged mode or parallel mode an you are just using one speaker lead to the cab you may get phase issues (if the bridged mode is not using output x). Make sure the amp is in stereo mode (this switches it to two mono block amps and use the corresponding inputs and outputs. Just use one channel of the amp (in case you are running stereo to a mono cab which will also cause problems). If running mono in the Axe make sure your I/O menu setting is correct and you are running the output to Copy L>R