Hi Radley. Well, I haven't tried the 22-button version, but I own the MMGT 16, which is the same only in a smaller version, and all I have to say is "wow"! RJM products are incredible pieces of gear and the MMGT is their flagship that will not disappoint. Before purchasing, I was looking at other controllers, but being that I already owned RJM's Rack Gizmo, I was confident in their build quality and most importantly, their impeccable customer service. Ron, Sherri and the RJM team are some of the best people you'll ever have the pleasure of working with if you need any sort of customer support.
Be mindful though... I was always used to owning controllers with many switches and was tempted to go with the 22-button for that reason, but instead chose the 16 for the smaller footprint and believe me, with the MMGT's ability to program switches to any given control and the option to designate "pages" that can switched with one tap of your foot, I am FAR from ever even being able to maximize the use of the 16. I thought I'd be using lots of pages and in reality, I'm only using 1-2 at this point in time. This is complimented by the AxeFX's use of "scenes" which help to minimize the workload of the controller as well.
I know there are some cheaper controllers out there that still offer the LCD screens and such, but I can't comment on their long-term support and roadworthiness, but I can say with confidence that if you choose the MMGT 10, 16 or 22, it will be the last controller you may ever have to buy. Feel free to contact directly if you have any specific questions regarding use and programming with the AFX. I'll be happy to share any info I know.