Gate/Expander position

This is a simple question, just something I've noticed but never really looked into. It seems like when I add a Gate/Expander block to cut noise, it works the same, no matter where in the layout I put it. On a real pedal board, for instance, I wouldn't put a noise gate first in the chain, prior to distortion or compression, but in the Axe layout, it doesn't seem to matter where it goes, a phenomenon that doesn't apply to most everything else. Anybody know why this is?
 
on the axe, it can only cause problems if you out it after time base effect, it will chop the tail end off.
 
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