I'll sheepishly admit my pedalboard is a little out of control, haha. Here's what's on it:
The biggest thing for me is that I tweak quite a bit while playing, and I'm just not comfortable with giving up the ability to change things on the fly. I've tried the route of "all in" with Helix, and pre-programming everything, but always ended up making a bunch of changes in Helix on the fly and it was cumbersome, and frankly time consuming.
I have about 10-12 songs preprogrammed in my PBC (Intro; verse; chorus; etc...) but I only do that on songs where I have to make a significant number of pedal changes between song sections (for example if I have to step on more than 4 pedals)... For 99% of what I'm doing I have a PBC preset that allows me to access any pedal via a switch, change between 3 different reverbs and 2 different delays subdivisions. I also have a page set up to access 8 different Mobius presets, so I have instant access to bit destroyer, filter, wah, flanger and other sounds.
I briefly tried the FC12, but I couldn't figure out how to get the same amount of control over the effects that I have via my PBC.