I use several drives and distorsions in my patches... Blackglass7K, Fat Rat, Rat Distorsion, T808 Mod, Mid Boost or FAS Boost driving real Alpha Omega as 3rd line (in loop, 1st is clean lows, 2nd drive from Axe, 3rd AO slightly driven, boosted for metal sounds). What is really interesting, I have similar patches for my Stingray 5 fretlees with Cobalt flatwounds, gives a lot of power in mix for energetic parts of my band songs.
Alpha Omega was purchased for other purposes, but I made na experiment and it extended the sound drastically (3rd and 4th mixed drives). It set in slightly higher (overlapping) frequencies than drive from line 2, gives more spectrum in middle highs. needles to say my basic sounfd utilizes 85% of CPU of Axe FX III...