In my mind, the way I like banks organized, is one for raw amps so I can hear each and then fiddle with it, one bank for "artist presets" that emulate well-known artist or song tones, and another bank for the super cool sounds/effects/ambience or non-guitar sounds. Then I create the bank i need for favorite presets/gigs. I'm now starting to group my presets into groups of 3 (not default 5) to make more space on the MFC for Scene/Up down; really, it's like having a 3 channel virtual amp for each up/down switch inside a bank.
The downside of the raw amp bank is so many amps have multiple flavors; you can get a lot of sounds out of a Plexi or Suhr Badger depending on gain settings and drive pedals (whcih as M@ says "change everything") for example, or the Dietzels which are very versatile if you fiddle with the gain. But it's a starting place for the amp canvas to fiddle around. X/Y can help some to get different flavors into a single preset but that's not really working right in beta Axe Edit 1.9 well, but from unit front panel can be done.
To organize, I try to dial in the amps first/set it up with a template using my fav effects but usually at room level or headphones....then you MUST re-adjust to do them at stage volume. With 128+ amps -- and the HUGE cab choice part of the equation -- this takes some serious time to do it WELL; harder if you've not actually ever heard each amp for real. Easier just to grab 10 or 20 amps already prefer/like the best and dial those in cold.
Not trying to go off poll topic; I agree with you, a raw amp bank being available really should highlight the AXE II for users/players, even if it comes as a fourth downloadable FW 11 Bank "D" on the Fractal website you can choose to overwrite another bank. I get amazed in meeting other users how many player just use the AXE II presets (which are great) and hardly ever program anything; those folks may never know the joys of playing an amp not currently contained in Bank A.