Attached to a different PC, works fine. I do have a lot of gear attached. USB hub as well. Midi to USB stuff, literally all kinds of stuff. This brings back nightmares of trying to load drivers and software for Eleven Rack, which would force you to reinstall your whole PC. YKIYK. So, I've tried a number of things to remedy this. Went basic. Unplugged EVERY damn thing besides axe FX, Uninstall, Reinstall, only usb 2.0, not 3.0 etc etc. Any basic thing you would try, I think I tried. Obviously there's a conflict. So I've reloaded Windows. It works now obviously. Now I'll spend the next 72 hrs reloading every app one at time, plugging in other devices one at a time. Not a big fan so far of the Axe FX drivers and whatever they don't like. The kuemper profiler stuff loaded fine :| Brand new to both units but wow, this blows.