I can never imagine wanting to! The Axe-Fx changes presets so fast... Just make 10 presets! You can already use CCs to change different things in different ways if you need more than one sound inside of a preset. Not just effect bypassing things either, but between settings where modifiers change different things in different ways. With the new X and Y thing there will be even more that you can do without changing presets. but seriously I can barely keep track of 383... 3830 would just be a mess to manage! You'd need one heck of a foot controller too for the extra 10 switches... Maybe it is a lack of imagination on my part, but I can only say that if this was a desirable thing, we would all be doing it by now.
So, to answer the original request. I love the axe-fx because it is easy to get the sounds from my head to my ears.
Maybe this is unclear.
Say you have your preset with a couple of nice amps and, just to stay small, 5 effects. You may want to have several different settings of your amps, from clean to bluesy to crunch to screaming lead and maybe some variations of them with different tones (hi/mid/bass). And the same for effects...maybe a slow chorus with hi depth, a stereo delay with 1/4 and 1/2 notes rhythms, a compressor, a long hall reverb and phaser is off. Now you need to go from your clean twin to a california lead and no chorus, a different delay setting, phaser on, compressor off and your reverb needs to be shorter, brighter and with more predelay and lesser modulation. Imagine to be able to use only ONE CC message to remote all these changes, type of amp and its setting, each fx on/off status and each effect parameters and imagine you can program and store up to ten of these statuses in your preset. Most MIDI pedalboards allow any switch to send out a CC message with a value, 1 to 128. Imagine that each switch sends out CC 1 with a different value, like 1-2-3-4-5-6-7-8-9-10.
You will be able to totally reconfigure your system with a single MIDI command! Especially because you can have huge strings of effects (footstomps and rack efx) in a preset and amps variations, your point of being impossible to use a large pedalboard with dozens of switches is taken care of...with this very simple approach.
You'll be able to do hundreds of changes with a single switch and no more than the number of switches in any MIDI pedalboard....
And for how fast a preset change can be, this approach will be always faster, with 0 latency. You'll change preset when a totally different chain and/or type of amps/efx will be needed, which may happen less frequently than you think, if you carefully program one of these presets I have described.
It's like having a control table in which you enter the values of your fx on/off status and their parameters AND your amps status and settings. Each set is tied to a master knob which is then remoted by a MIDI CC. So each click of this master knob is a whole set of values for all your rig. That is smart!
It's just a simple thing that can add value to a very powerful and versatile platform like the AXE FX.
How can this be unuseful?
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