Windows 10. No problem switching off the Axe-FX III while Axe-Edit is open
However, I have another issue with the USB:
if I switch on the Axe-FX III while there is a sound playing at the computer (YouTube, system sounds or whatever) then the Axe-FX USB dies; there is no sound coming from it. Then I have to uninstall the Fractal Audio drivers, restart the computer and install them again (same solution as the OP).
No issues after I have disabled the PC system sounds and take care of not playing anything while I switch On the Axe-FX
Consensus of majority of users without this problem does not mean that the OP doesn't have an issue. Democracy is not a cure for diseases.
Anyway, like in my case, he has found a reliable solution