i wouldn't run the output of the axe into a mic pre, because the axe runs at line level and a mic pre does not. wrong tool for the job. there's a reason that mic pre's exist and that's to take the output of a microphone and turn it into a line level signal. use the line inputs on your audio interface from the analog outs, or go via usb or spdif. i can't hear a significant difference between analog and digital in this scenario, so i choose to go analog and then i'm not forced to use 48k in my projects.
The OP was about running: guitar -> preamp -> Fractal
To me this can be good if you have a favorite DI or HI-Z preamp that you track with. No different than using a real amp to me.