If I am recording, I tend to build my guitar tones to fit the mix. I like to have everything going into the recording shaped to fill the right spot of the mix so that there is very minimal EQ and compression going on, and mostly adjusting levels to balance everything. I'm new to recording, so I'm sure people will tell me I'm doing things wrong, but so far my mixes sound pretty good on everything I've tested from headphones, cellphone, car, and my monitors. I tend to start with my drums. I use EZ Drummer 2 with multiple packs you can get from them. My drum tone is based on the style of music, so I pick and choose the drum kit pieces and adjust the sound accordingly. Then I adjust my bass tone to compliment the drums, but stand out from it as well. Then I build my guitar tones to blend in yet stand out from the drums and bass. In the end, its mostly level balancing and panning stuff to make it sit right and the whole mix sound full, but not muddy, and every instrument defined, yet sitting nicely. I end up using minimal EQ and some compression (usually on some of the drumming and bass stuff, rarely on my guitar stuff). Everyone has a different approach, so I am sure as I get more experience recording, my approach and methods will change over time.