I'd say its the exact opposite. I found my Atomic CLR's (far cheaper, plus easier to carry than a Marshall head and 4x12) as simple as plug in, turn on, play. Sound amazing without any need for tweaking, and that sound is evenly heard across the stage.
Problem I always had with real cabs is the directional nature of them. It could sound great when I'd stand slightly off axis, but in front of it was too harsh and beaming, yet then other people couldn't hear it on the other side of the stage, so I'd turn up, and then audience in front was getting blasted, just never ending issue with volume and dispersion. My CLR sounds as good on axis as far off axis, and drummers, etc all reported how much easier they could hear me, even though I actually had less volume than normal. Furthermore, I can easily ramp the levels up and down without significant changes in tone, which was problematic when I was running a NMV amp as sometimes I'd be requested to turn it down to the point where the tone would suffer.
CLR has been a dream for me, works as a wedge, works as a backline, even can be put on a pole and used as a FOH speaker. 2 inputs as well so you can run vocals etc into it as well. Fantastic for smaller gigs, and if the venue does have a decent FOH system its easy to adjust the levels of using it as a personal stage monitor or side fill roll.
If there is another guitarist using a cab though that may prove a little difficult, depending on how he/she likes to hear themselves on stage. Certainly some folks like to hear themselves, even if its detrimental to the rest of the band/audience.
Overall though the pros far outweigh the cons, at least for me.
I sold my amp and cab for more than enough to pay for two CLR's and have a good bit left over, and while I have the heavier-non neo version of the CLR, I can still carry it with one hand, it fits into my trunk or backseat etc, which my 4x12 never did, and it sounds better and more consistent in more environments.
Your miliage may vary of course, but I found it as simple as just plug in it into my AX8, go to the HBE patch with default cab, turn up the levels to the intensity level I wanted and it sounded just perfect. Exactly the tone I was always trying to get from my real cabs, without any concerns about directional beaming or levels, mic'ing things, etc.