Gonna try that... Any tip?
Sure! I could go on forever, but I'll keep it to a few. I can post a preset too when I get back home in a couple weeks if you're interested. I just realized while typing this that I haven't turned on the AxeFX in almost 2 weeks...
For reference I'm using it primarily as a lead amp, using HSH configuration (I dialed it up on my Charvel Pro Mod DK24). I really like it in pickup position 2 and 4 where the single coil is blended with a coil split humbucker. Kinda Nick Johnston-esque sound if you're into that.
With all that in mind...
1) I like it with Greenbacks. I used an Ownhammer mix that's primarily GB with a little G12H30 mixed in, on the darker and more focused end of their mixes, but this is purely taste and application dependent of course.
2) The EQ knobs don't make big swings in overall tone, they're more of a distortion control for that frequency band. I don't know for sure, but I assume it's the location of the tone controls in the signal chain more similar to a Mesa Mark Series... maybe someone else on here can confirm/deny that or explain why it behaves this way. Anyway, use those knobs to set up the distortion as you like and use the cab and the graphic EQ in the amp block to shape the overall tone.
3) I like to keep the bass knob down to get a clean and punchy fundamental (it does this very well), so I set up a "mid gain" amp setting with the low cut on and bass knob down, then I boost it with the Timothy Drive with even more low cut to get at higher gain settings to keep it clean. Then if more low end is needed, do it in the graphic EQ to make it fat but not flubby.
4) Leave the master volume knob dimed as it defaults as a non-master volume amp.