can i unplug the usb as i please safely?

No problems here dis/re connecting multiple times. No need to disable device. Driver seems very solid on XP sp3.
 
Absolutely. However, any applications (either ASIO or MIDI) using this device at the time it's disconnected may get confused, so ideally you would close such applications before turning off or shut down the Axe-Fx II.
 
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