Real world, I usually only have 1 or 2 cabs, that tend to be favorites and loaded with speakers I like. Simply never has been practical to have say 15 different cabs sitting in the corner. Now of course with the Axe, swapping cabs is as easy as turning a dial, and for $29 or so you can add tons of new cabs options from an IR pack, which again, would cost probably $2900 or more to buy the real things, so what a great digital age we live in.
At the same time though, just because we've got 2,000+ IR's to choose from doesn't mean we need to try to use all of them, just like even though the Axe has 200+ amps, I still use maybe 5.
One could view this as not taking advantage of all the unit offers, and I can see that point of view, BUT, for me, its more that I have all those choices to let me zero exactly in on what are my perfect amps and cabs. I had 200 choices to get exactly what I wanted.
Its like if I was a million selling artist and said I wanted a great Fender tone, and send my asst. engineer out to procure every amp Fender has made, and then I auditioned all of them, keeping my favorite. That really is what the Axe lets you do, basically sample a ton of choices and pick your very favorite 1 or 2 models. Others are going to be very good, but maybe not get that last percent tone your after. Wouldn't make sense to own 10 similar real world amps, so doesn't make sense to use 10 similar models just because they are there.