The OP reported that Drive block was the first one showing red. It could be a bug in the Drive block (could also be elsewhere).
I had this issue more than a few times, and I can report it happens to different kind of blocks. It starts with some block having one channel (usually the lower one) as red, as the other channel as empty, no signal. All blocks after that are always red.
That's why I fail to reproduce it every time. But it's very similar to this bug which is reproducible on many FWs, and might (or might not) be a key to the issue reported here:
https://forum.fractalaudio.com/thre...-between-rows-mutes-fm3-until-restart.208462/
I also don't attach presets to issues which are reproducible on every preset in a box, like
https://forum.fractalaudio.com/threads/fm3-firmware-version-9-01.208627/post-2609950.
I also didn't report this issue because of exactly this line:
3. Simplify the preset as much as possible. Remove any blocks that are not relevant.
Once the issue happened, you can create a blank preset with different number, and the sound will be there while only In and Out blocks are connected. Adding literally any block, Volume, GEQ, Amp, doesn't matter, automatically marks it as red on Meters page. Removing if from the grid doesn't help as Out is also red at the point. You have to remove-add Out again for sound to come back.
Once the unit is restarted, the issues goes away for many weeks.
I've attached a preset to the issue in the first link ("moving Send") because this I can reproduce. I'm pretty sure Fractal support cannot spend days on the issue which is reported by a couple of people once in a blue moon, so I see no reason to bug them with the report of issue in this thread. But I'll attach the preset next time, you are right, maybe it's the combination or anything.