Best Setup to connect to a DAW

[fantomi]

I own an Axe Fx 3, an Focusrite Interface with S/PDIF and now i want to connect it to my DAW on a Mac.

I also want to use a Keyboard that is connected to the Mac.

What is the Best Setup?

 

[AxtEffekt]

Best is relative, but an easy way would be a USB cable only, i.e. using your Axe FX III as the audio interface. Other than that, you can use the S/PDIF connection from the Axe into the Focusrite.

 

[trb]

Both USB and S/PDIF will provide the same quality.

 

[Sustainerplayer]

I'm on Mac as well. I go S/PDIF into my interface. If I want to re-amp I make an aggregate device with my Axe III and interface.

My keyboards either go direct to the computer via USB - or via my interface via it's MIDI 5-pin in. That's for MIDI only.
If you want the sounds from your keyboard you connect that to your interface.