Axe II and Matrix GT1000FX = GREAT !!!

No. You CAN, but dont have to.

Personally, I run all my FX, then take a branch off to the FX loop, which sends the signal to OP 2, the Matrix and my cab. After the branch I add a cab block, and a PEQ which then goes to OP 1 and FOH (for when needed). I only do this as OP 1 has XLR outs which is better for FOH.

the only thing there is you cant any FX post cab block, or they wont be present in you one stage amp/cab sound. I can live with that.
 
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