I am STILL very new with the Axe-FX... Definitely the suggestions given to you already are great starting points, which also served me well BUT, as "noob" as well, these 10 "noob rules" worked great for me (and they are based in my own experience):
1. if you are buying used, MAKE SURE you RESET all parameters.
2. Set up your input gain to the LOUDEST of your guitars
3. Update to the LATEST firmware.
4. Upload ALL the Quantum Presets and use them as starting points.
- 4A. Alternatively, get Fremen's presets, they are outstanding.
- 4B. Other option: Erase ALL presets and just copy what you think you would need.
5. Learn to use BOTH the front of the panel of the Axefx AND Axe-Edit!
6. If you start building presets, BACK THEM UP!
7. Tweaking is your friend, but learn WHERE to tweak based on what you are trying to achieve (SOMETHING I am still STRUGGLING with)
8. Are you recording? figure if you want to use USB, spdif, or analog outputs to your interface.
9. Figure out HOW you are going to connect your AxeFx to your Cab/frfr monitor and to the FOH (if applicable). Learn to use BOTH outputs.
10. Most important ONE: HAVE FUN and DON'T be AFRAID to ask questions.
Good luck!
Omar