This makes sense. I only have a QSC powered speaker — would that work?The ML preset that you are referring to (and all of the Factory presets) is very likely intended for FRFR systems. The preset was dialed in using one of his awesome IRs. When using a 'real' cab, all bets are off. Even if your power amp is working correctly, and you bypass the Cab block, it will sound very different than the headphones/FRFR.
Try a passive FRFR/PA speaker with your power amp if you have, or can borrow one to rule out the power amp as the issue.
I have tried creating a preset with just an amp in the chain (I used the SOLO100) and I still could not get away from the thin sound. Is there a preset I could try that is more geared towards my setup?