So my signal chain will go from my Axe into Neural DSP like Plini or Amplitube and I'm LOVING the tones I'm getting. For the Axe I go from input->compressor->Distortion->Amp->output. I will use VSTs for other distortions/effects on top and use their cabs. If you focus on cleaning up the signal to noise ratio in your axe-fx, you will have some fantastic sounds by the end. To me, I have gotten significantly better sounds than if I was to use just the axe or just vsts. Has anyone else used this method?