PCs often have two different USB busses, with different capacities. Move your cable around to different ports because that can make a difference.
When I first started using my Fractal on my Mac, I had problems with the connection being dropped and tried several different things to isolate the problem. I removed all USB drives and devices, including other hubs, and plugged the Fractal directly in, confirmed it worked, then started re-adding the other devices. Eventually, I found that my secondary hub, which was powered also, wasn't able to keep up with my Fractals (I have all three and often have them doing backups or installs at the same time). I bought a better-powered hub, and have had almost no problems since.
If you use the Fractal like an audio card then, when streaming audio and doing backups/installs or updates, the hardware is going to run out of CPU in my experience. The Fractal seems to give its processing priority over the incoming audio processing, understandably. I try to not stream when I'm pushing the system like that. I've had no problem when streaming a track and playing over it or recording though.
Windows can be a real pain when it comes to drivers, so make sure you've always got the
current driver for the Fractals.