Axe Fx III clock settings?

Hi, I'm using Pro Tools 12 with Windows and I have a problem with pops and noises when I connect my Axe Fx 3 to my audio interface when I record via SPDIF or XLR connection, the only solution I found is using the Axe as audio interface
Can you help me?
 
If he has pop and noises even when running thru XLRs I doubt it's an SPDIF related issue.
I'd check interface buffer settings, cpu usage on the axe fx or clipping
 
Couldn't the word clock settings potentially affect all inputs and outputs in the Axe FX since it affects the AD/DA converters?
 
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