I have not done a blind test between my AFX2 and FX8, but it would be a pretty quick test. The difference in sound and feel is very obvious. One uses blind tests to eliminate bias, but if anything, I was biased in favor of the AFX2 working! Believe me, I did not want to shell out an additional $1400 for an FX8 in order to have something that would work with my tube amp. I worked with it for weeks, posted questions on here, used every combination of outputs, settings, pads, etc. Questions on here were typically met with the same incredulous responses, but the fact is it simply did not have the transparent sound and immediate response I got from using my pedals. So I used my pedalboard with my tube amp, used my AFX2 for direct to FOH, and eagerly awaited the arrival of the FX8. I got one of the first FX8's shipped, and it was an epiphany. The instant I plugged it in, the superiority over the AFX2 both in the effects loop and in 4CM was obvious. No fiddling around with settings and output pads, it just worked instantly, and it FELT like being plugged into the amp. The "thwack" had returned.
Both are amazing for their intended purpose, and especially with the recent Quantum FW updates to the Axe, it's gotten so great for direct to FOH that I practically never use my tube amp anymore. But when I do, it's with the FX8.