Meh... Synergy is pretty kick ass as far as a tube solution goes. I have the SYN-30 combo with a REAL 6L6 clean tone onboard that sounds excellent. I'm using the Friedman Dirty Shirley module for broken up tones and the second channel for rock leads and it kicks total ass. A KILLER 3 channel combo, perfect FX loop, MIDI controllable, analog cab simulated DI out (which is very good, made me actually sell the FM3 first time around) and you can defeat the cab sim and use IR's.
This time around I will be using the FM3 in conjunction with the SYN-30 for IR loader, post FX. I'll also use it in front or 4CM including MIDI channel switching.
The Fractal stuff sounds amazing, but FRFR will never come close to a real amp.
I will also be testing FM3 into the FX return of the SYN-30 as well.
There is a place for both, but with tons of hands on with the Synergy stuff -- including gigging a lot -- I can tell you it's pretty killer!