For what it's worth, I have intermittent connectivity issues with OSX High Sierra 10.13.4 on an iMac Pro via USB. At times it connects with no problem, but occasionally it will show it's connected on the top, but none of the patch info is available or modifiable. Sometimes rebooting fixes it, sometimes not. It's unpredictable, without any hardware changes or other identifiable reason for the disconnect.
Also, is it necessary to have AxeEdit re-read the entire user cab list every time you startup? It's slow and there's no change in my user cab list it would need to be updating. Not an error so much as a wish list I suppose.