First here is my thread I created regarding this issue for some back history:
https://forum.fractalaudio.com/thre...imeouts-with-8b-q8-q8-01.127089/#post-1512090
My problem started on 8beta. I tried everything: replacing cables, usb ports, disengaging global blocks, used different computers, used different axefx IIs, reinstalled firmware - axe edit (AE) - usb driver (adjusting buffer settings), you name it. I kept screenshots of most timeout messages I have. I can post those if you need, but need to compile them. I even sent my axefx off to support and after a week of them running it through the ringer at 90%+ cpu usage they couldn't get it to disconnect from AE. So we deduced that it had to be something on my computer. So, I stopped using Chrome, Sonar X3 and even windows media player (all sources I use to learn songs/program presets on a weekly basis for my church service) and only when they all were closed did I have somewhat success with AE not disconnecting (which, if it did, I'd have to reboot both my Axefx and my PC... every time).
Preface: Ever since Fall of 2011 I have used my AxeFX as my sole audio interface. I've used it with 5 different PCs without constant disconnects like I have with 8b-8.01. Occasionally, it would disconnect, but it wasn't too often.
Here's my solution after 3 days with zero problems. I spoke to Charlie at FAS and I thought that perhaps the audio interface processing side of my axefx was perhaps being put under strain since I was running presets ~73-84% cpu usage and getting constant AE crashes. So, while i was waiting for my axefx to be returned I ordered a Focusrite Scarlett 2i2 and put it in place of my axefx for processing. I can now keep my axefx connected, just as it has been this whole time, and not get a single disconnect. AE runs faster too now. Not only that, but I've been able to add 3-4 more effects in my chain which bumped up cpu usage to 85-90% usage with zero problems. Now, note I have only done this on my friends axefx that I have been borrowing from my friend (which also had disconnects like mine when i update it), but have not yet tried this with mine, but will after Sunday when I have time.
So short and sweet answer to fix this issue, I got another audio interface to take the load off my axefx and so far it's worked without a hitch. I do believe something (probably accidental and unintentional) happened with 8b+ b/c so many people are having this same problem. But this work around is working fine for me and was only $118 shipped.