I just ordered this 2 days ago, immediately went to the Plexi 6CA7 preset as this is what I've been using for my dirt and lead sounds. This setting totally blew me away. So much better than what I had in my own preset. Gigged last night with it using the '59 Bassman model for clean and this for dirt/lead and great and cutting tone with my tele.
Now to explore the other sounds, though I don't know if I'll find better than these.
Those two presets/amp models along the RJM Archon and also in my "go-to's" right now. My P90 Les Paul loves that Bassman.