Regrets? Not one! The Axe-Fx was literally a dream come true for me. During 30 years of playing, I had a whole host of traditional and software based systems previously - tube amps (Fender, MusicMan, GK, Marshall, Boogie... had a London Power on order...) modeling amps (Line6, Vox, Hughes & Kettner), pedal effects by the dozens, rack gear (you name it, from power strips to vintage digital to Eventide H8000) plus virtual rigs-- Guitar Rig, Amplitube, etc., and then power amps, speaker cabs, and much much more.
The Axe-Fx (and my pair of Reactor FRs) satisfies to the fullest extent.
It not only gives more playing enjoyment, it cures all GAS, as you'll hear many say. Creative type? You'll love tinkering. Set it and forget it type? Spend a little time dialing it in and YOUR SOUND will be there, with room to spare for exploration if you feel inclined.
This community is also a part of the "no regrets" equation. Being able to find answers, share successes, and simply observe as others do the same is of great value to me. The "wisdom of crowds" is in full effect here. There is an overall excitement and energy I just don't find often. People LOVE this thing, and this passion is reflected in aspects of individual ownership everywhere.
As for things taking a lot of work, I do disagree. I, and many others can get great tones inside of the very first session. The thing just WORKS for my ears. I won't use words like "magic" or "monster" for fear of unfavorable comparison to stupid marketing campaigns elsewhere, but it sure makes me happy to sit with my Axe-Fx and a guitar.
Also, it's made me some great friends-- from rockstars lilke Dweezil Zappa to forum superheroes like Sean, Scott, Jay, Steve, Yek... (please don't hold it against me if you're not listed here guys!) to friendly online newcomers to people in my own neighborhood.
Zero regrets. On the contrary-- 101% "would buy again in a heartbeat."