yek
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That can affect the tone and response of certain pedals though, often for the worse, as the effect loop runs at a line level. My analogman nkt germanium fuzz for example sounds and responds to the volume pot very differently in the loop, just as it does when it’s behind a buffered pedal etc
I run some modulation effects in the loop, like the SA Vertigo and it sounds great anywhere, but some pedals IMO, need to be first in the signal chain for “best” or authentic response, tone and interaction
My comment was solely targeted at comparing the real and virtual pedals.
BTW, the line level off the effects loop can easily be adjusted with the Output 2 knob. The impedance is the same as the front input.